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Those skilled in the art will appreciate that for intranasal administration or delivery, because the volume of the pharmaceutical composition administered is generally small, nasal secretions may alter the pH of the administered dose since the range of pH in the nasal cavity can be as wide as 5 to 8. Such alterations can affect the concentration of un-ionized drug available for absorption. Accordingly, in representative embodiments, the pharmaceutical composition further comprises a buffer to maintain or regulate pH in situ. Typical buffers include, but are not limited to, ascorbate, acetate, citrate, prolamine, carbonate, and phosphate buffers. In embodiments of the invention, the pH of the pharmaceutical composition is selected so that the internal environment of the mucosal tissue after administration is on the acidic to allegra to dogs side, which (1) can provide the active compound in an un-ionized form for absorption, (2) prevents growth of pathogenic bacteria, which is more likely to occur in an alkaline environment, and (3) reduces the likelihood of irritation of the mucosa. For liquid and powder sprays or aerosols, the pharmaceutical composition can be formulated to have any allegra to dogs and desired particle or droplet size. In illustrative embodiments, the majority andor the mean size of the particles or droplets range from equal to or greater than about 1, 2. 5, 5, 10, 15 or 20 microns andor equal to or less than about 25, 30, 40, 45, 50, 60, 75, 100, allegra d walgreens generic list, 150, 175, 200, 225, 250, 275, 300, 325, 350, 375, 400, or 425 microns (including all combinations of the foregoing). Representative examples of suitable ranges for the majority andor mean particle or droplet size include, without limitation, from about 5 to 100 microns, from about 10 to 60 allegra bettini, from about 175 to 325 microns, and from about 220 to 300 microns which facilitate the deposition of an effective amount allegra pediatrics bellevue wa the active compound, for example, in the nasal cavity (e.in the upper third of the nasal cavity, the superior meatus, the olfactory region andor the sinus region to target the olfactory neural pathway).

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