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NRAS, IDH, PTPN11, FLT3, and chromatinspliceosome mutations) (Fig. S15 in the Supplementary Appendix). Other significant genegene interactions were found. In particular, the prognosis was significantly poorer than expected for the co-occurrence of FLT3 TKD mutations with partial tandem duplications of MLL (q0. 008) and for the co-occurrence of DNMT3A with IDH2 R140 (q0. 05) ( Figure 4C and 4D and Table 2 ).

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