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Indicaciones terapéuticas: Antihistamínico. Alivio de los síntomas asociados a: rinitis alérgica como estornudos, rinorrea, prurito nasal, en paladar y faringe; irritación, prurito y lagrimeo ocular en niños de 2 a 11 años de edad. Urticaria idiopática crónica, en niños de 6 meses a 11 años de edad. Farmacocinética y farmacodinamia: Farmacodinamia: el principio activo de ALLEGRA es el clorhidrato de fexofenadina, un antihistamínico no sedante con actividad antagonista selectiva sobre los receptores H 1 periféricos. El clorhidrato de fexofenadina inhibe el broncoespasmo inducido por antígenos en cobayos sensibilizados, y la liberación de histamina de los mastocitos peritoneales en ratas. En animales de laboratorio, no se observaron efectos bloqueadores del receptor alfa 1 -adrenérgico o anticolinérgico.

The remaining free coordinate site can then participate in a Haber-Weiss interaction in the presence of H 2 O 2generating hydroxyl radical. This reaction could be amplified if there is reducing potential, such as O 2 or ascorbate, available to cycle the iron to a ferrous state. In addition to the reducing potential of ascorbate, it is of a size and configuration that it fits in the anion coordinate sites of lactoferrin, limiting stabilized carbonate-Fe 3 binding.]